Chronic lymphocytic leukemia (CLL), the most frequent form ofleukemia in Western countries, is characterized by the clonalproliferation and accumulation of neoplastic B lymphocytes inthe blood, bone marrow, lymph nodes, and spleen. The medianage of patients at diagnosis is 65 years, with only 10 to 15percent under 50 years of age. In most series, more men thanwomen are affected. The course of the disease is variable. Whereassome patients with CLL have a normal life span, others die withinfive years after diagnosis. During the past few years, importantadvances have been made in the . . . [Full Text of this Article]
Cause
Diagnostic Criteria
Natural History
Treatment
Early and Stable Disease
Advanced CLL with a Large Tumor Burden and Bone Marrow Failure
Cytopenias Due to an Immune Mechanism or Hypersplenism
Treatment of Systemic Complications
New Treatment Approaches
Purine Analogues
Transplantation of Hematopoietic Progenitors
Biotherapy
Source Information
From the Postgraduate School of Hematology "Farreras Valentí, " Department of Medicine, University of Barcelona, Hospital Clínic, Barcelona, Spain.
Address reprint requests to Prof. Rozman at the Postgraduate School of Hematology "Farreras Valentí," Hospital Clínic, Villarroel, 170-08036 Barcelona, Spain.
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A correction has been published: N Engl J Med 1995;333(22):1515.
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