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Case Records of the Massachusetts General Hospital
Weekly Clinicopathological Exercises
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Volume 333:1135-1143 October 26, 1995 Number 17
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Case 33-1995— Progressive neurologic deterioration with unusual findings on magnetic resonance imaging in a 43-year-old man treated for demyelinating disease
M. Ronthal, and J.-P. Vonsattel

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Presentation of Case

A 43-year-old right-handed paraplegic man was admitted to the hospital because of increasing confusion and aphasia, increasing fatigue, weight loss, and new decubitus ulcers.

The patient had been well until four years earlier, when diplopia, ataxia, dysarthria, and lethargy developed. A lumbar puncture was performed (Table 1). A magnetic resonance imaging (MRI) scan of the brain (Figure 1) showed increased T2-weighted signal intensity in the pons, which extended into the midbrain, cerebellum, and posterior limb of the internal capsules, with swelling of those structures and slight ventricular enlargement; there was minimal enhancement with gadolinium. Corticosteroids . . . [Full Text of this Article]

Differential Diagnosis

Clinical Diagnosis

Dr. Michael Ronthal's Diagnosis

Pathological Discussion

Anatomical Diagnosis

References




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