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Editorial
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Volume 333:1146-1148 October 26, 1995 Number 17
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Mitochondrial Toxicity — New Adverse Drug Effects

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Hepatitis B virus (HBV) infection has a major impact on the public health because of its frequency, morbidity, and late consequences. In the United States about 200,000 primary HBV infections occur annually. Between 5 and 10 percent of patients with primary infection become chronically infected. There are probably 750,000 to 1 million HBV carriers in the United States, and worldwide the number of carriers is 200 million to 300 million. Each year in the United States as many as 5000 patients die of chronic HBV infection (about 4000 from cirrhosis and 600 to 1000 from complicating liver cancer).1 Hence, considerable . . . [Full Text of this Article]

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N Engl J Med 1996; 334:1135-1138, Apr 25, 1996. Correspondence

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