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Previous Volume 333:1222-1224 November 2, 1995 Number 18 Next

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To the Editor: Sheremata et al. (June 8 issue)¹ reported severe necrotizing cutaneous lesions complicating treatment with interferon beta-1b in a patient with multiple sclerosis. They indicated that it was a new complication of treatment with interferon beta-1b, which had not been observed with natural or recombinant interferon alfa. However, we described a case of cutaneous necrosis caused by the injection of interferon alfa in a patient with chronic myelogenous leukemia.² Cutaneous necrosis due to interferon alfa was also reported by Cnudde et al.³ and subsequently by Orlow and Friedman-Kien⁴ in patients with Kaposi's sarcoma related to the acquired immunodeficiency . . . [Full Text of this Article]

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Related Letters:

Severe Necrotizing Cutaneous Lesions Complicating Treatment with Interferon Beta-1b
Sheremata W. A., Taylor J. R., Elgart G. W.
Extract | Full Text  
N Engl J Med 1995; 332:1584-1585, Jun 8, 1995. Correspondence

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