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Previous Volume 333:1224-1225 November 2, 1995 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The clinical manifestations and evolution of hepatitis C virus (HCV) infection are thought to be influenced by the viral genotype and by the immunoreactivity of the infected person.¹ These factors sometimes also determine the appearance of liver–kidney–microsomal autoantibodies type 1 (LKM-1).² We report discordant manifestations and evolution of HCV infection in a pair of monozygotic twins (with a probability of monozygosity greater than 99 percent).³ One had acute hepatitis and recovered fully. The other had chronic hepatitis associated with the appearance of LKM-1 autoantibodies.

The two men, both 20 years of age, share the HLA haplotype A2,11;B8,44;DR3,4;DQ2,3. . . . [Full Text of this Article]

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