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Previous Volume 333:1283-1284 November 9, 1995 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The apolipoprotein E gene is present in the general population in three alleles, 2, 3, and 4, with 3 being common and 2 and 4 relatively less common. Genetic-linkage and association studies have shown that the 4 allele is overrepresented¹ and the 2 allele is underrepresented² in patients with Alzheimer's disease. These observations are now generally accepted and have been replicated in numerous clinic-based, case–control studies. In this issue of the Journal, Polvikoski et al.³ describe the results of an investigation of the relation of the apolipoprotein E genotype to the development of Alzheimer's disease in a prospectively studied cohort . . . [Full Text of this Article]

References

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