Stroke is the third leading cause of death in the United States,after coronary heart disease and cancer. There are approximately500,000 cases of stroke each year; of these, 150,000 are fatal.1Many survivors are left with mental and physical impairmentand require assistance with activities of daily living. Twenty-eightpercent of patients with stroke are under 65 years of age, andwomen account for 40 percent of the new cases.2 Blacks in theUnited States have a rate of mortality due to stroke roughlytwice that of whites.3 There are over 3 million patients withstroke alive in the . . . [Full Text of this Article]
Hypertension
Smoking
Glucose Tolerance
Obesity
Physically Active Lifestyle
Serum Cholesterol
Diet
Alcohol
Fat and Fatty Acids
Antioxidants
Low-Dose Aspirin
Women and Hormone Treatment
Low-Dose Oral Contraceptives
Postmenopausal Estrogen-Replacement Therapy
Healthy People 2000
Source Information
From the Division of Preventive Medicine and the Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School (L.L.B., J.E.M.); the Department of Epidemiology, Harvard School of Public Health (L.L.B.); and the NeurologyNeurosurgery Intensive Care Unit and the Division of Neurology, Brigham and Women's Hospital (D.S.K.) all in Boston; and Harvard Community Health Plan in Peabody, Mass. (J.E.M.).
Address reprint requests to Dr. Manson at 900 Commonwealth Ave. East, Boston, MA 02215.
References
Related Letters:
Primary Prevention of Stroke
Martinez-Riera A., Santolaria-Fernandez F., Gonzalez-Reimers E., Perry I. J., Gilbert R.E., Jerums G., Cooper M.E., Bronner L. L., Kanter D. S., Manson J. E.
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N Engl J Med 1996;
334:1138-1139, Apr 25, 1996.
Correspondence
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Shreeve, S. M., Shatos, M. A., Thorin, E.
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[Full Text]