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Correspondence
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Volume 333:1429 November 23, 1995 Number 21
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Diltiazem and Subacute Cutaneous Lupus Erythematosus–Like Lesions

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To the Editor: Calcium-channel blockers are associated with rashes, including light-induced and lichenoid eruptions. An association with lupus erythematosus has been reported, although the patient and the nature of the lesion were not described.1

In four patients (two men and two women, 76 to 81 years old) subacute lupus erythematosus–like eruptions developed during treatment with diltiazem. All four had light-induced eruptions and positive tests for antinuclear antibodies, with antibodies to Ro in three patients and to La in two. None of the patients had marked extracutaneous disease. Diltiazem had been used for an average of 2.5 years before the development . . . [Full Text of this Article]

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