To the Editor: Calcium-channel blockers are associated withrashes, including light-induced and lichenoid eruptions. Anassociation with lupus erythematosus has been reported, althoughthe patient and the nature of the lesion were not described.1
In four patients (two men and two women, 76 to 81 years old)subacute lupus erythematosuslike eruptions developedduring treatment with diltiazem. All four had light-inducederuptions and positive tests for antinuclear antibodies, withantibodies to Ro in three patients and to La in two. None ofthe patients had marked extracutaneous disease. Diltiazem hadbeen used for an average of 2.5 years before the development. . . [Full Text of this Article]
References
This article has been cited by other articles:
Saladi, R. N., Cohen, S. R., Phelps, R. G., Persaud, A. N., Rudikoff, D.
(2006). Diltiazem induces severe photodistributed hyperpigmentation: case series, histoimmunopathology, management, and review of the literature.. Arch Dermatol
142: 206-210
[Abstract][Full Text]
Srivastava, M., Rencic, A., Diglio, G., Santana, H., Bonitz, P., Watson, R., Ha, E., Anhalt, G. J., Provost, T. T., Nousari, C. H.
(2003). Drug-Induced, Ro/SSA-Positive Cutaneous Lupus Erythematosus. Arch Dermatol
139: 45-49
[Abstract][Full Text]
Ghate, J. V., Turner, M. L., Rudek, M. A., Figg, W. D., Dahut, W., Dyer, V., Pluda, J. M., Reed, E.
(2001). Drug-Induced Lupus Associated With COL-3: Report of 3 Cases. Arch Dermatol
137: 471-474
[Abstract][Full Text]
Olsen, J. H., Sorensen, H. T., Friis, S., McLaughlin, J. K., Steffensen, F. H., Nielsen, G. L., Andersen, M., Fraumeni, J. F. Jr, Olsen, J.
(1997). Cancer Risk in Users of Calcium Channel Blockers. Hypertension
29: 1091-1094
[Abstract][Full Text]