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Previous Volume 333:1498-1501 November 30, 1995 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The ongoing shortage of human organs and tissues for transplantation, coupled with scientific and biotechnological advances, has catalyzed new attempts to use animal tissues in humans — a field known as xenotransplantation. Pigs and nonhuman primates have been used as sources of organs, with limited success.^1,2 Recently, the transplantation of baboon bone marrow to attempt to reconstitute the immune system in patients with AIDS was proposed,³ and fetal-pig mesencephalon cells are being studied for the treatment of patients with refractory parkinsonism.

The use of xenogeneic tissues in transplantation has raised concern about potential infection with both recognized zoonotic pathogens and . . . [Full Text of this Article]

Is There a Risk for Transplant Recipients?

Is There a Potential Threat to the Public Health?

How Can the Public Health Risks Be Minimized?

Address reprint requests to Dr. Chapman at Mailstop G-19, Retrovirus Diseases Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333.

References

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• Martina, Y., Marcucci, K. T., Cherqui, S., Szabo, A., Drysdale, T., Srinivisan, U., Wilson, C. A., Patience, C., Salomon, D. R. (2006). Mice transgenic for a human porcine endogenous retrovirus receptor are susceptible to productive viral infection.. J. Virol. 80: 3135-3146 [Abstract] [Full Text]  
• Florencio, P. S., Ramanathan, E. D. (2004). Legal Enforcement of Xenotransplatation public Health Safeguards. J Law Med Ethics 32: 117-123  
• Chapman, L. E., Bloom, E. T. (2001). Clinical Xenotransplantation. JAMA 285: 2304-2306 [Full Text]  
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• Czauderna, F., Fischer, N., Boller, K., Kurth, R., Tönjes, R. R. (2000). Establishment and Characterization of Molecular Clones of Porcine Endogenous Retroviruses Replicating on Human Cells. J. Virol. 74: 4028-4038 [Abstract] [Full Text]  
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• Vanderpool, H. Y. (1999). Commentary: A Critique of Clark's Frightening Xenotransplantation Scenario. J Law Med Ethics 27: 153-157  
• Hunt, S. A. (1998). Current Status of Cardiac Transplantation. JAMA 280: 1692-1698 [Abstract] [Full Text]  
• Akiyoshi, D. E., Denaro, M., Zhu, H., Greenstein, J. L., Banerjee, P., Fishman, J. A. (1998). Identification of a Full-Length cDNA for an Endogenous Retrovirus of Miniature Swine. J. Virol. 72: 4503-4507 [Abstract] [Full Text]  
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