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Previous Volume 333:1507-1508 November 30, 1995 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Prioleau and Schnitt (June 1 issue)¹ reported a potential problem of p53 antigen loss in slides that had been stored at room temperature for two months. We examined slides that had been cut from formalin-fixed, paraffin-embedded blocks containing a p53-positive colorectal carcinoma and accidentally stored at room temperature for periods of 6 to 14 months. We found that the p53 reactivity could be restored with a method of antigen retrieval² based on heating the slides in a microwave oven.

We examined slides from four patients with colorectal carcinoma in situ that did not stain for p53 by . . . [Full Text of this Article]

References

Related Letters:

p53 Antigen Loss in Stored Paraffin Slides
Prioleau J., Schnitt S. J.
Extract | Full Text  
N Engl J Med 1995; 332:1521-1522, Jun 1, 1995. Correspondence

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• Shi, S.-R., Cote, R. J., Taylor, C. R. (1997). Antigen Retrieval Immunohistochemistry: Past, Present, and Future. J. Histochem. Cytochem. 45: 327-344 [Abstract] [Full Text]