FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 333:1562-1563 December 7, 1995 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Changes in pituitary–thyroid function occur in patients with virtually all illnesses and those undergoing major surgical procedures. Although such changes are referred to as the euthyroid sick syndrome, the key changes — namely, decreases in serum triiodothyronine and thyroxine concentrations — have multiple causes, vary considerably in different patients, and very likely have different effects on different tissues. Although we have generally assumed that the decreases have no pathophysiologic consequences, it is by no means clear that the patients are in fact euthyroid.

The most common change is a decrease in extrathyroidal conversion of thyroxine to triiodothyronine, the active form . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Pingitore, A., Galli, E., Barison, A., Iervasi, A., Scarlattini, M., Nucci, D., L'Abbate, A., Mariotti, R., Iervasi, G. (2008). Acute Effects of Triiodothyronine (T3) Replacement Therapy in Patients with Chronic Heart Failure and Low-T3 Syndrome: A Randomized, Placebo-Controlled Study. J. Clin. Endocrinol. Metab. 93: 1351-1358 [Abstract] [Full Text]  
• Ullah, S., Zabala, L., Watkins, B., Schmitz, M. L (2006). Cardiac organ donor management. Perfusion 21: 93-98 [Abstract]  
• Colantuoni, A., Marchiafava, P. L., Lapi, D., Forini, F. S., Iervasi, G. (2005). Effects of tetraiodothyronine and triiodothyronine on hamster cheek pouch microcirculation. Am. J. Physiol. Heart Circ. Physiol. 288: H1931-H1936 [Abstract] [Full Text]  
• Iervasi, G., Pingitore, A., Landi, P., Raciti, M., Ripoli, A., Scarlattini, M., L'Abbate, A., Donato, L. (2003). Low-T3 Syndrome: A Strong Prognostic Predictor of Death in Patients With Heart Disease. Circulation 107: 708-713 [Abstract] [Full Text]  
• Bartkowski, R., Wojtalik, M., Korman, E., Sharma, G., Henschke, J., Mrowczynski, W. (2002). Thyroid hormones levels in infants during and after cardiopulmonary bypass with ultrafiltration. Eur. J. Cardiothorac. Surg. 22: 879-884 [Abstract] [Full Text]  
• Biondi, B., Palmieri, E. A., Lombardi, G., Fazio, S. (2002). Effects of Thyroid Hormone on Cardiac Function - The Relative Importance of Heart Rate, Loading Conditions, and Myocardial Contractility in the Regulation of Cardiac Performance in Human Hyperthyroidism. J. Clin. Endocrinol. Metab. 87: 968-974 [Abstract] [Full Text]  
• Lazarus, J H, Obuobie, K (2000). Thyroid disorders---an update. Postgrad. Med. J. 76: 529-536 [Full Text]  
• Wartofsky, L., Burman, K. D., Ringel, M. D. (1999). Trading One "Dangerous Dogma" for Another? Thyroid Hormone Treatment of the "Euthyroid Sick Syndrome". J. Clin. Endocrinol. Metab. 84: 1759-1759 [Full Text]