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Previous Volume 333:1572 December 7, 1995 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Losartan (Cozaar, Merck) is a new, orally effective blocker of the angiotensin II receptor. The currently available angiotensin-converting–enzyme (ACE) inhibitors block the degradation of bradykinin, which is also metabolized by ACE. The accumulation of potent vasodilator kinins is believed to be the cause of cough and angioneurotic edema induced by ACE inhibitors. Because losartan does not have ACE activity, it would not be expected to increase bradykinin levels.¹ The drug has therefore been advocated as being potentially free of these adverse effects. However, angioneurotic edema did occur in 1 patient among 4058 treated.¹ We report another case . . . [Full Text of this Article]

References

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• Cicardi, M., Zingale, L. C., Bergamaschini, L., Agostoni, A. (2004). Angioedema Associated With Angiotensin-Converting Enzyme Inhibitor Use: Outcome After Switching to a Different Treatment. Arch Intern Med 164: 910-913 [Abstract] [Full Text]  
• Grossman, E., Messerli, F. H., Neutel, J. M. (2000). Angiotensin II Receptor Blockers: Equal or Preferred Substitutes for ACE Inhibitors?. Arch Intern Med 160: 1905-1911 [Full Text]  
• KASHYAP, A S, MATHEW;, I, GIBBS, C., LIP, G. Y., BEEVERS, D G. (1999). ACE inhibitors and angioedema. Postgrad. Med. J. 75: 188c-188 [Full Text]  
• KANAZAWA, H., HIRATA, K., YOSHIKAWA, J. (1999). Guinea Pig Airway Hyperresponsiveness Induced by Blockade of the Angiotensin II Type 1 Receptor . Role for Endogenous Nitric Oxide. Am. J. Respir. Crit. Care Med. 159: 165-168 [Abstract] [Full Text]