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Previous Volume 333:1688-1694 December 21, 1995 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Testing of thyroid function is common in clinical practice. Many patients who are tested, including those who have or are receiving treatment for thyroid disease, take medications that may affect thyroid function. Therefore, the possible effect of these drugs both on the results of thyroid-function tests and on the effectiveness of treatment must always be considered in decisions regarding patient care.

The pathways of thyroid hormone synthesis, secretion, transport in the circulation, and metabolism offer numerous targets for drug interaction (Figure 1 and Figure 2). Normal thyroid secretion depends on thyrotropin (TSH). Secretion of TSH is, in turn, . . . [Full Text of this Article]

Drugs Affecting the Secretion of TSH

Drugs Affecting the Secretion of Thyroid Hormone

Drugs That Cause Hypothyroidism

Drugs That Cause Hyperthyroidism

Drugs Affecting T₄ Absorption

Drugs Affecting T₄ and T₃ Transport in Serum

Increases in Serum TBG Concentrations

Decreases in Serum TBG Concentrations

Inhibition of the Binding of T₄ and T₃ to TBG

Metabolism of T₄ and T₃

T₄ 5'-Deiodinase

Thyroid Dysfunction Caused by Cytokines

Conclusions

Source Information

From the Division of Endocrinology, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, N.Y.

Address reprint requests to Dr. Surks at the Montefiore Medical Center, 111 East 210th St., Bronx, NY 10467.

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