Angiogenesis is fundamental to reproduction, development, andrepair. All these processes depend on the tightly regulatedgrowth of blood vessels that can "turn on" and "turn off" withina brief period. When blood vessels grow unabated, angiogenesisbecomes pathologic and sustains the progression of many neoplasticand non-neoplastic diseases. The realization that tumor growthrequires new blood vessels and the identification of chemicalfactors that mediate angiogenesis have broadened our understandingof pathologic processes and opened new avenues to the diagnosisand treatment of these diseases.
Tumor hypervascularity was initially thought to reflect inflammatoryvasodilation of preexisting host vessels, a . . . [Full Text of this Article]
Angiogenesis in Neoplastic Disease
Angiogenesis in Non-Neoplastic Disease
Clinical Applications
Diagnostic and Prognostic Applications
Therapeutic Acceleration of Angiogenesis
Therapeutic Inhibition of Angiogenesis
Interferon Alfa-2a to Treat Life-Threatening or Sight-Threatening Hemangiomas
Ocular Neovascularization
Arthritis
Cancer
General Principles of Antiangiogenic Therapy
Future Directions
Source Information
From the Departments of Surgery and Cell Biology, Harvard Medical School; and the Department of Surgery, Children's Hospital — both in Boston.
Address reprint requests to Dr. Folkman at Children's Hospital, Hunnewell 103, 300 Longwood Ave., Boston, MA 02115.
References
Related Letters:
Angiogenesis and Tumor Growth
van Netten J. P., Cann S. A., van der Westhuizen N. G., Paran H., Paran D., Puglisi F., Scalone S., DiLauro V., Folkman J.
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N Engl J Med 1996;
334:920-921, Apr 4, 1996.
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Flaxenburg, J. A., Melter, M., Lapchak, P. H., Briscoe, D. M., Pal, S.
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