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Previous Volume 333:234-240 July 27, 1995 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Calcium ions are essential for a wide variety of biologic functions, including vital extracellular processes, such as blood clotting, intercellular adhesion, and skeletal integrity, as well as intracellular processes, such as the regulation of hormonal secretion, cell division, and cell motility.^1,2,3,4 Complex, free-living terrestrial organisms must maintain a near-constant concentration of extracellular calcium. How the body maintains and regulates extracellular calcium levels is a complex puzzle that has intrigued researchers for decades.^3,4,5 One large piece of this puzzle that is falling into place concerns a cell-surface receptor that responds to, or "senses," extracellular calcium-ion concentrations in parathyroid, kidney, and other . . . [Full Text of this Article]

Control of Mineral-Ion Metabolism

Indirect Evidence of a Calcium-Ion–Sensing Cell-Surface Receptor

Cloning of a Bovine Receptor Sensitive to Calcium Ions

Mutations in the Calcium-Ion–Sensing Receptor Gene

Mutations That Inactivate the Calcium-Ion–Sensing Receptor

Mutations That Overactivate the Calcium-Ion–Sensing Receptor

The Calcium-Ion–Sensing Receptor and Extracellular Calcium Homeostasis

Source Information

From the Endocrine–Hypertension (E.M.B.), Cardiology (C.E.S.), and Renal (M.P., D.R., S.C.H.) Divisions, Department of Medicine, Brigham and Women's Hospital, and the Department of Genetics (M.P., J.G.S., Y.-H.W.C.) and Howard Hughes Medical Institute (C.E.S., J.G.S.), Harvard Medical School — both in Boston.

Address reprint requests to Dr. Brown at the Endocrine–Hypertension Division, Brigham and Women's Hospital, 221 Longwood Ave., Boston, MA 02115.

References

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