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Previous Volume 333:251-253 July 27, 1995 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Nitric oxide is as simple chemical substance whose many biologic roles have only recently been appreciated. First discovered by Furchgott and Zawadzki as an endothelium-dependent vasodilating substance (endothelium-derived relaxing factor) in the vasculature,¹ this product of the normal endothelial cell is an important regulator of vascular tone. The identification of endothelium-derived relaxing factor as nitric oxide was independently established in 1987 by Ignarro and colleagues² and Palmer and coworkers.³ Although nitric oxide is a structurally simple heterodiatomic molecule, it has an array of complex biochemical actions that evoke a wide range of biologic effects.⁴

Nitric oxide is synthesized by the . . . [Full Text of this Article]

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