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In 1933 the Cold Spring Harbor Laboratory on Long Island, New York, became the site of an annual meeting on a topic of interest in biology. The subject of the 1966 meeting was the genetic code; the following year's meeting, devoted to antibodies, attempted to build on the previous symposium by bringing the precepts of molecular biology to immunology. A great deal had been learned about the structure of immunoglobulins, thanks to new methods for sequencing proteins, but in 1967 the genetic basis of antibody diversity remained as mysterious as ever. Indeed, it was not until 1976, almost a decade
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