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Previous Volume 333:356-363 August 10, 1995 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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A peptidergic activity produced in endothelial cells that caused coronary vasoconstriction was described in 1985,¹ and a family of peptides, named the endothelins, was subsequently isolated and identified.² The three members of the family — endothelin-1, endothelin-2, and endothelin-3 — are produced in a variety of tissues, where they act as modulators of vasomotor tone, cell proliferation, and hormone production. Studies with endothelins and specific endothelin-receptor antagonists have suggested that these peptides are important in vascular physiology and disease. This article reviews the important details of the synthesis and actions of endothelins and the roles of endothelins in organ function . . . [Full Text of this Article]

Cell Biology

Endothelin-1

Endothelin-2 and Endothelin-3

Biochemistry and Molecular Biology

            Endothelin Peptides

            Endothelin Receptors

            Type A Endothelin Receptors

            Type B Endothelin Receptors

Regulation and Expression of Endothelin Receptors

Physiology of Endothelins

Interactions with Other Vasoactive Factors in the Vasculature

Circulatory Effects of Endothelin-1

Pathophysiology of Endothelins

Cardiovascular Pathology

Hypertension

Pulmonary Function and Disease

Kidney Disease

Developmental Disorders

Central Nervous System Effects

Physiology

Brain Ischemia

Subarachnoid Hemorrhage

Conclusions

Source Information

From the Departments of Medicine and Pharmacology, University of California, Irvine, Irvine, and the Long Beach Veterans Hospital, Long Beach, Calif.

Address reprint requests to Dr. Levin at Long Beach Veterans Hospital, Medical Service (111-I), 5901 E. 7th St., Long Beach, CA 90822.

References

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