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A 46-year-old woman was admitted to the hospital for consideration of lung transplantation because of severe pulmonary hypertension.
The patient had been well and working as a secretary until 16 months earlier, when proximal-muscle weakness developed, accompanied by myalgia, Raynaud's phenomenon, scaling plaques over the distal interphalangeal joints, and a maculopapular rash over the face, neck, and anterior chest that spared the eyelids and nasolabial folds; she began to have dyspnea. Evaluation elsewhere showed that the creatine kinase level was approximately 3000 U per liter. Electromyographic studies revealed evidence of muscle disease. Microscopical examination of a quadriceps musclebiopsy specimen disclosed
Differential Diagnosis
Clinical Diagnosis
Dr. David S. Lazarus's Diagnoses
Pathological Discussion
Anatomical Diagnosis
References
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