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Previous Volume 333:384-385 August 10, 1995 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Sudden death, a devastating event for any family, strikes more than 300,000 Americans each year. Cardiac arrhythmias, particularly ventricular arrhythmias, are thought to account for about 11 percent of all sudden deaths. In some cases there appears to be a familial propensity for sudden death. One inherited condition, the Romano–Ward long-QT syndrome, is an autosomal dominant disorder of cardiac repolarization that results in ventricular arrhythmias and sudden death. The long-QT syndrome has been thought to arise from either an abnormality of ion-channel regulation (the myocellular hypothesis) or altered activity of the autonomic nervous system, but definitive proof of either hypothesis . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Hoppe, U. C., Marban, E., Johns, D. C. (2001). Distinct gene-specific mechanisms of arrhythmia revealed by cardiac gene transfer of two long QT disease genes, HERG and KCNE1. Proc. Natl. Acad. Sci. USA 98: 5335-5340 [Abstract] [Full Text]  
• Dorostkar, P. C., Eldar, M., Belhassen, B., Scheinman, M. M. (1999). Long-Term Follow-Up of Patients With Long-QT Syndrome Treated With {beta}-Blockers and Continuous Pacing. Circulation 100: 2431-2436 [Abstract] [Full Text]  
• Maron, B. J., Moller, J. H., Seidman, C. E., Vincent, G. M., Dietz, H. C., Moss, A. J., Towbin, J. A., Sondheimer, H. M., Pyeritz, R. E., McGee, G., Epstein, A. E. (1998). Impact of Laboratory Molecular Diagnosis on Contemporary Diagnostic Criteria for Genetically Transmitted Cardiovascular Diseases: Hypertrophic Cardiomyopathy, Long-QT Syndrome, and Marfan Syndrome : A Statement for Healthcare Professionals From the Councils on Clinical Cardiology, Cardiovascular Disease in the Young, and Basic Science, American Heart Association. Circulation 98: 1460-1471 [Full Text]  
• Towbin, J. A., Friedman, R. A. (1998). Prolongation of the QT Interval and the Sudden Infant Death Syndrome. NEJM 338: 1760-1761 [Full Text]  
• Schulze-Bahr, E., Haverkamp, W., Funke, H., Towbin, J. A. (1995). The Long-QT Syndrome. NEJM 333: 1783-1784 [Full Text]  
• Estes, N.A. M. (1995). Sudden Death in Young Athletes. NEJM 333: 380-381 [Full Text]