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Correspondence
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Volume 333:522-523 August 24, 1995 Number 8
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Nitric Oxide and Motor Neuron Disease

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To the Editor: Tsai and Gastfriend (April 13 issue)1 report the case of a 58-year-old woman with primary pulmonary hypertension and a history of alcohol abuse in whom profound weakness developed after a bilateral lung transplantation. They state, "After receiving nitric oxide as a pulmonary dilator postoperatively for 15 days, she was found to be paralyzed and areflexic." The authors believe that nitric oxide treatment and the up-regulation of N-methyl-d-aspartate (NMDA) receptors by chronic alcoholism "may have caused extensive lower motor neuron disorder." There are several problems with this hypothesis. First, the localization is uncertain; second, more likely diagnoses . . . [Full Text of this Article]

References


Related Letters:

Nitric Oxide–Induced Motor Neuron Disease in a Patient with Alcoholism
Tsai G. E., Gastfriend D. R.
Extract | Full Text  
N Engl J Med 1995; 332:1036, Apr 13, 1995. Correspondence



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