FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 333:532 August 24, 1995 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited

Edited by J.G. Grudzinskas, T. Chard, M. Chapman, and H. Cuckle. 346 pp. New York, Cambridge University Press, 1995. $89.95. ISBN 0-521-45271-6.

Screening for fetal Down's syndrome first became possible in the late 1960s, when the positive association between maternal age and the prevalence of Down's syndrome at birth was identified and a diagnostic test (amniocentesis and fetal karyotyping) became available. Until the 1980s, the screening test essentially was the question, "How old are you?" If the pregnant woman was, for example, 35 or older, she was offered counseling and diagnostic testing. In 1984, it was reported that fetal Down's syndrome was associated with reduced maternal levels of serum alpha-fetoprotein in the second trimester and that this reduction was independent of maternal . . . [Full Text of this Article]

HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  HELP  |  beta.nejm.org Comments and questions? Please contact us. The New England Journal of Medicine is owned, published, and copyrighted © 2008 Massachusetts Medical Society. All rights reserved.