FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 334:28-33 January 4, 1996 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Correct regulation of gene expression, so that specific proteins are made by the appropriate organs at the appropriate times or in response to specific signals, is essential both to normal development and to the correct functioning of the adult organism. Such regulation is usually achieved at the level of DNA transcription, a process that controls which genes are transcribed into RNA by the enzyme RNA polymerase, although regulation also occurs after transcription.¹

The transcription of specific genes is controlled by regulatory proteins known as transcription factors.^2,3 These factors therefore have a vital function in both embryonic development and the response . . . [Full Text of this Article]

Developmental Disorders

Disorders of Hormone Response

Oncogenic Transcription Factors and Cancer

Antioncogenic Transcription Factors and Cancer

Prospects for Therapy

Source Information

From the Department of Molecular Pathology, University College London Medical School, Windeyer Bldg., Cleveland St., London W1P 6DB, United Kingdom, where reprint requests should be addressed to Professor Latchman.

References

This article has been cited by other articles:

• Sanchez-Martin, M., Rodriguez-Garcia, A., Perez-Losada, J., Sagrera, A., Read, A. P., Sanchez-Garcia, I. (2002). SLUG (SNAI2) deletions in patients with Waardenburg disease. Hum Mol Genet 11: 3231-3236 [Abstract] [Full Text]  
• Karamouzis, M. V., Gorgoulis, V. G., Papavassiliou, A. G. (2002). Transcription Factors and Neoplasia: Vistas in Novel Drug Design. Clin. Cancer Res. 8: 949-961 [Abstract] [Full Text]  
• Matzner, Y., Abedat, S., Shapiro, E., Eisenberg, S., Bar-Gil-Shitrit, A., Stepensky, P., Calco, S., Azar, Y., Urieli-Shoval, S. (2000). Expression of the familial Mediterranean fever gene and activity of the C5a inhibitor in human primary fibroblast cultures. Blood 96: 727-731 [Abstract] [Full Text]  
• Donovan, C. E., Mark, D. A., He, H. Z., Liou, H.-C., Kobzik, L., Wang, Y., De Sanctis, G. T., Perkins, D. L., Finn, P. W. (1999). NF-{kappa}B/Rel Transcription Factors: c-Rel Promotes Airway Hyperresponsiveness and Allergic Pulmonary Inflammation. J. Immunol. 163: 6827-6833 [Abstract] [Full Text]  
• Morishita, R., Higaki, J., Tomita, N., Ogihara, T. (1998). Application of Transcription Factor "Decoy" Strategy as Means of Gene Therapy and Study of Gene Expression in Cardiovascular Disease. Circ. Res. 82: 1023-1028 [Abstract] [Full Text]  
• Ahmad, W., Faiyaz ul Haque, M., Brancolini, V., Tsou, H. C., ul Haque, S., Lam, H., Aita, V. M., Owen, J., deBlaquiere, M., Frank, J., Cserhalmi-Friedman, P. B., Leask, A., McGrath, J. A., Peacocke, M., Ahmad, M., Ott, J., Christiano, A. M. (1998). Alopecia Universalis Associated with a Mutation in the Human hairless Gene. Science 279: 720-724 [Abstract] [Full Text]  
• Yue, Z., Maldonado, E., Pillutla, R., Cho, H., Reinberg, D., Shatkin, A. J. (1997). Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II. Proc. Natl. Acad. Sci. USA 94: 12898-12903 [Abstract] [Full Text]  
• Schwartz, R. S. (1997). The Case of the Bare Lymphocyte Syndrome -- Tracking Down Faulty Transcription Factors. NEJM 337: 781-783 [Full Text]  
• Dhundale, A., Goddard, C. (1996). Reporter Assays in the High Throughput Screening Laboratory: A Rapid and Robust First Look?. J Biomol Screen 1: 115-118