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Previous Volume 334:42-45 January 4, 1996 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The feasibility of using DNA as a treatment has been demonstrated in animal models, but clinical applications of this form of technology remain elusive. When gene therapy does come into wide medical use, it may be as a vaccine. Difficulties in developing vaccines against chronic infections with viral agents such as the human immunodeficiency virus (HIV), herpes simplex virus, and hepatitis C virus are partly due to the poor immunogenicity of standard vaccines; these problems have spurred the development of new vaccine strategies that use DNA instead of protein.

DNA vaccines contain the gene or genes for an antigenic portion . . . [Full Text of this Article]

Source Information

From the Division of Gastroenterology, Department of Internal Medicine, University of Michigan School of Medicine, and the Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Mich.

Address reprint requests to Dr. McDonnell at 111D Internal Medicine, Ann Arbor Veterans Affairs Medical Center, 2115 Fuller Rd., Ann Arbor, MI 48105.

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