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Correspondence
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Volume 334:53-55 January 4, 1996 Number 1
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Drug-Resistant Streptococcus pneumoniae

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 by Pallares, R.
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 by Hofmann, J.
To the Editor: Since the first description of infection caused by {beta}-lactam–resistant Streptococcus pneumoniae, the optimal empirical antibiotic therapy for patients with suspected meningitis caused by this microorganism has remained unknown. Hofmann et al. (Aug. 24 issue)1 reported a 25 percent prevalence of penicillin-resistant S. pneumoniae isolates and a 9 percent prevalence of cephalosporin-resistant isolates among 431 patients with invasive pneumococcal infections in Atlanta. The authors recommended adding vancomycin to the initial therapeutic regimen of patients with suspected pneumococcal meningitis. Their suggestion appears questionable because they did not present the susceptibility patterns of the meningeal strains or discuss morbidity and . . . [Full Text of this Article]

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