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Previous Volume 334:863-864 March 28, 1996 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In Dr. Lee's excellent review of drug-induced hepatotoxicity (Oct. 26 issue),¹ he recommends a 48-hour course of oral N-acetylcysteine for patients who have ingested acetaminophen at an unknown time before coming to the hospital or in whom the dose ingested appears excessive. This statement deserves clarification. If the regimen Lee proposes is implemented, many patients will be treated and hospitalized unnecessarily, and the most critically ill patients may be undertreated. When either the dose or the time of ingestion is unclear, determining both the serum acetaminophen level and the aspartate aminotransferase level may be helpful in . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Wallace, K. P., Center, S. A., Hickford, F. H., Warner, K. L., Smith, S. (2002). S-Adenosyl-L-Methionine (SAMe) for the Treatment of Acetaminophen Toxicity in a Dog. Journal of the American Animal Hospital Association 38: 246-254 [Abstract] [Full Text]