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Correspondence
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Volume 334:864-865 March 28, 1996 Number 13
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Management of Acquired Bullous Skin Diseases

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 by Fine, J.-D.
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 by Roujeau, J.-C.
To the Editor: On the basis of personal experience and "in the hope that very early intervention . . . in a patient with still relatively limited involvement . . . may prevent more extensive epidermal necrosis," Fine (Nov. 30 issue)1 recommends systemic corticosteroid therapy in patients with toxic epidermal necrolysis. We have argued against the use of this therapy.2 This difference of opinion reflects the absence of well-controlled evaluations of corticosteroid therapy in such patients.

The arguments for the use of corticosteroid therapy are based on the probable immune-mediated mechanism of toxic epidermal necrolysis and on small series in . . . [Full Text of this Article]

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