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Previous Volume 334:965-972 April 11, 1996 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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During the 20th century, there have been recurrent episodes of cocaine abuse in the United States that have achieved epidemic proportions.¹ Although the total number of people using the drug has decreased in the past decade, cocaine-related biomedical and psychosocial problems remain a major public health problem in the United States and many other countries. The expanding list of cocaine-related toxic effects, acute and chronic, includes reproductive dysfunction, hepatic necrosis, and pulmonary disease.² Abuse of and dependence on cocaine may also be associated with disorders of sexual function, sleep, anxiety, and mood, as well as with delirium and psychotic disorders. . . . [Full Text of this Article]

Diagnostic Criteria

Pharmacologic Effects and Mechanisms of Abuse and Dependence

Pharmacotherapy for Cocaine Abuse and Dependence

Antidepressant Drugs

Drugs Affecting Dopaminergic Function

Opioid Antagonists and Mixed Agonist–Antagonists

Carbamazepine

Psychotherapy and Behavioral Therapy

New Medications — Promises and Problems

Conclusions

Source Information

From Harvard Medical School, Boston, and McLean Hospital, Belmont, Mass.

Address reprint requests to Dr. Mendelson at McLean Hospital, 115 Mill St., Belmont, MA 02178.

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