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Previous Volume 334:1128 April 25, 1996 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Emphysema can cause substantial functional impairment and is one of the leading causes of death in the United States. Our ability to treat emphysema is severely limited because the principal physiologic deficiency results from the destruction of the architecture of the lung. The development of lung transplantation, first of a single lung and later of both in sequence, was the first direct approach to the treatment of advanced emphysema. However, most patients with severe disease are precluded from undergoing this surgery by advanced age and coexisting conditions. In addition, the postoperative regimen of immunosuppression causes substantial morbidity and mortality. Lung-reduction . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Criner, G. J., Scharf, S. M., Falk, J. A., Gaughan, J. P., Sternberg, A. L., Patel, N. B., Fessler, H. E., Minai, O. A., Fishman, A. P., for the National Emphysema Treatment Trial Researc, (2007). Effect of Lung Volume Reduction Surgery on Resting Pulmonary Hemodynamics in Severe Emphysema. Am. J. Respir. Crit. Care Med. 176: 253-260 [Abstract] [Full Text]  
• Berger, R. L., Celli, B. R., Meneghetti, A. L., Bagley, P. H., Wright, C. D., Ingenito, E. P., Gray, A., Snider, G. L. (2001). Limitations of randomized clinical trials for evaluating emerging operations: the case of lung volume reduction surgery. Ann. Thorac. Surg. 72: 649-657 [Abstract] [Full Text]  
• WEG, I. L., ROSSOFF, L., MCKEON, K., MICHAEL GRAVER, L., SCHARF, S. M. (1999). Development of Pulmonary Hypertension after Lung Volume Reduction Surgery. Am. J. Respir. Crit. Care Med. 159: 552-556 [Abstract] [Full Text]