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Volume 334:1195-1197 May 2, 1996 Number 18
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Teratogenicity of High Vitamin A Intake

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 by Rothman, K. J.
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To the Editor: The article by Rothman et al. (Nov. 23 issue)1 followed our study, in which we identified a possible increase in the risk of certain birth defects associated with vitamin A supplementation, but information on dose was not available.2 We are pleased that their study examined this relation according to the dose of retinol, but the methods used raise several questions.

Information on pregnancy outcomes was obtained from the delivering physician or the mother; both are considered poor sources of information on birth-defect diagnoses, but we cannot evaluate the accuracy of ascertainment without knowing the range and distribution . . . [Full Text of this Article]

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