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Previous Volume 334:1264-1265 May 9, 1996 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The ability of the human immunodeficiency virus (HIV) to replicate successfully in vitro appears inextricably linked to the state of activation of its cellular host. Indeed, an activated cellular environment is crucial for both the initial phase of the HIV life cycle involving reverse transcription and the establishment of the HIV provirus within the host chromosome and the subsequent expression of these proviral genes and the directed assembly of infectious virions.¹ Hints that the state of cellular activation is just as important for viral replication in vivo emerged when viral gene expression was preferentially detected in the germinal centers of . . . [Full Text of this Article]

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