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Previous Volume 334:1409-1410 May 23, 1996 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Prenatal screening and diagnostic services for fetal Down's syndrome have been offered to women since the early 1970s, when reliable techniques of chromosome analysis became available. Screening was initially based only on the pregnant woman's age but has been broadened in recent years, first with the discovery of maternal serum alpha-fetoprotein^1,2 and then with the discovery of additional maternal serum markers.^3,4 Although it has been possible to document the number of pregnant women who choose certain prenatal screening services,⁵ little information is available about the use of diagnostic services, including decisions about terminating or continuing affected pregnancies.

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References

This article has been cited by other articles:

• Chan, A. (2003). Invited Commentary: Parity and the Risk of Down's Syndrome--Caution in Interpretation. Am J Epidemiol 158: 509-511 [Full Text]  
• Palomaki, G. E., Williams, J. R., Haddow, J. E. (1999). Prenatal Screening for Open Neural-Tube Defects in Maine. NEJM 340: 1049-1050 [Full Text]