A diverse system of adhesion molecules and adhesion receptorsparticipates in orchestrating vital biologic phenomena, suchas embryogenesis, cell growth and differentiation, and woundrepair. Over the past decade there has been immense progressin our understanding of adhesion molecules and their complexinteractions. We review the main classes of adhesion receptorsand give examples of diseases in which they have been foundto be involved.
Among the many types of adhesion receptors on the cell surface,four major families stand out (Figure 1). The integrins aremembrane glycoproteins with two subunits, designated and .An important feature . . . [Full Text of this Article]
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From the Center for Blood Research and the Department of Pathology, Harvard Medical School, 800 Huntington Ave., Boston, MA 02115, where reprint requests should be addressed to Dr. Wagner.
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Droge, W.
(2002). Free Radicals in the Physiological Control of Cell Function. Physiol. Rev.
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Harari, O. A., Marshall, D., McHale, J. F., Ahmed, S., Haskard, D. O.
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Thomson, A. J., Telfer, J. F., Young, A., Campbell, S., Stewart, C. J.R., Cameron, I. T., Greer, I. A., Norman, J. E.
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Smith, S., Skerrett, S. J., Chi, E. Y., Jonas, M., Mohler, K., Wilson, C. B.
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Fornaro, M., Manzotti, M., Tallini, G., Slear, A. E., Bosari, S., Ruoslahti, E., Languino, L. R.
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153: 1079-1087
[Abstract][Full Text]
Gerli, R., Paolucci, C., Gresele, P., Bistoni, O., Fiorucci, S., Muscat, C., Belia, S., Bertotto, A., Costantini, V.
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92: 2389-2398
[Abstract][Full Text]
Pantoni, L., Sarti, C., Inzitari, D.
(1998). Cytokines and Cell Adhesion Molecules in Cerebral Ischemia : Experimental Bases and Therapeutic Perspectives. Arterioscler. Thromb. Vasc. Bio.
18: 503-513
[Abstract][Full Text]
Barron, M. K., Lake, R. S., Buda, A. J., Tenaglia, A. N.
(1997). Intimal Hyperplasia After Balloon Injury Is Attenuated by Blocking Selectins. Circulation
96: 3587-3592
[Abstract][Full Text]
Fiocchi, C.
(1997). Intestinal inflammation: a complex interplay of immune and nonimmune cell interactions. Am. J. Physiol. Gastrointest. Liver Physiol.
273: G769-G775
[Abstract][Full Text]