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Previous Volume 334:1537-1539 June 6, 1996 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Neuroblastoma is the most enigmatic of neoplasms of children because of its variable clinical behavior: it may regress spontaneously in infants, mature into a benign ganglioneuroma in older patients, or grow relentlessly and be rapidly fatal.¹ Neuroblastomas are also heterogeneous histopathologically, with a spectrum ranging from the most undifferentiated neuroblastomas to fully mature, benign ganglioneuromas. Tumors in intermediate stages of differentiation are referred to as ganglioneuroblastomas. Three notable changes occur during the progression from primitive neuroblastoma to differentiated ganglioneuroma: neuroblasts mature and come to resemble ganglion cells, the number of mitotic or karyorrhectic (dying) cells decreases, and much of the . . . [Full Text of this Article]

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