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Previous Volume 334:1544 June 6, 1996 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Considine and coworkers (Feb. 1 issue)¹ report that obese subjects have elevated serum leptin concentrations that decrease during weight reduction. The authors conclude that "most obese persons are insensitive to endogenous leptin production." We do not believe that this conclusion necessarily follows from the results of their study.

Body weight is regulated by complex mechanisms involving numerous afferent metabolic and hormonal signals informing the brain about the body's energy status. insulin, cholecystokinin, and cortisol are just a few examples of these signals.² Abnormal production or action of any of the afferent messengers may lead to weight gain. . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Buchowski, M. S., Simmons, L. A., Chen, K. Y., Flakoll, P. J., Mellen, B. G., Turner, E. A. (2000). Plasma Leptin Association with Body Composition and Energy Expenditure in Sickle Cell Disease. J. Am. Coll. Nutr. 19: 228-236 [Abstract] [Full Text]