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Correspondence
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Volume 334:1610-1611 June 13, 1996 Number 24
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Deficiency of Adhalin in a Patient with Muscular Dystrophy and Cardiomyopathy

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 by Fadic, R.
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To the Editor: Deficiency of the dystrophin-associated protein adhalin has been associated with autosomal recessive muscular dystrophy. The report by Fadic et al. (Feb. 8 issue)1 advances our understanding of the dystrophin complex by identifying a child with both cardiomyopathy and muscular dystrophy and a deficiency of adhalin on immunostaining of both the heart and skeletal muscle. However, the authors failed to acknowledge that three different genes have been identified that, when mutated, result in decreased immunostaining for adhalin. The first is the chromosome 17 adhalin gene. The second gene maps to chromosome 13q12 and encodes the 35-kd dystrophin-associated protein . . . [Full Text of this Article]

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