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After a progressive decline that began in the 19th century, the incidence of tuberculosis in the United States began to climb again in the mid-1980s. This resurgence of tuberculosis was due to a number of factors, including the epidemic of HIV infection, homelessness in urban areas, and immigration from countries with a high prevalence of the disease. Unfortunately, the public health infrastructure needed to deal with this resurgence had deteriorated badly. To complicate matters further, there was now a whole generation of physicians with little training or experience in the diagnosis and treatment of tuberculosis. Biomedical research on the disease
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