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Correspondence
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Volume 334:333-334 February 1, 1996 Number 5
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Hydroxyurea in Sickle Cell Disease

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 by Charache, S.
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To the Editor: We wish to comment further on the possible risks of hydroxyurea therapy in sickle cell disease, a subject of considerable attention since the results of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia were reported by Charache et al. (May 18 issue).1

We agree that the caution advised by Ho and Murgo2 and Silver3 in their letters (Oct. 12 issue) is necessary. Unfortunately, the single sentence from our editorial4 quoted by Ho and Murgo distorts the thrust of our paragraph on the long-term safety of hydroxyurea. Continued monitoring of patients with sickle cell disease and others . . . [Full Text of this Article]

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