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Since the two cardinal and generally dramatically overt clinical events caused by vascular disease are occlusion and rupture, it is quite natural, as the introductory chapter of this book notes, that solutions to vascular problems have developed from the innate plumbing instincts of surgeons. Vascular surgery has flourished amid an impressive array of technical achievements, but even as frontiers have been broadly advanced over the past half century, surgeons have been haunted by an awareness that less pliable biologic processes lurking at the cellular and biochemical level will ultimately frustrate definitive cure. It has become abundantly clear that control of
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