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Previous Volume 334:362-366 February 8, 1996 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Cardiac muscle is commonly affected in muscular dystrophies.^1,2,3,4 X-linked Duchenne's muscular dystrophy and Becker's muscular dystrophy are caused by mutations in the gene encoding dystrophin,^5,6 a membrane cytoskeletal protein.⁷ In skeletal and cardiac muscle, dystrophin is associated with a large oligomeric complex of sarcolemmal glycoproteins.^8,9 This dystrophin–glycoprotein complex is composed of five glycoproteins (35, 43 doublet, 50, and 156 kd) and two proteins (25 and 59 kd). It spans the sarcolemma to provide linkage between the subsarcolemmal cytoskeleton and laminin, a major component of the extracellular matrix.^9,10

In Duchenne's and Becker's muscular dystrophies, the primary deficiency in dystrophin is associated . . . [Full Text of this Article]

Case Report

Methods

Muscle-Biopsy Specimens

Antibodies

Results

Discussion

Source Information

From the Departments of Neurology (R.F., A.J.W., P.J.L., B.P.L.) and Pediatrics (S.B.), University of Wisconsin, Madison, and the Howard Hughes Medical Institute and the Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City (Y.S., K.P.C.).

Address reprint requests to Dr. Lotz at the Department of Neurology, University of Wisconsin Hospital and Clinics, 600 Highland Ave., Madison, WI 53792.

References

Related Letters:

Deficiency of Adhalin in a Patient with Muscular Dystrophy and Cardiomyopathy
McNally E., Bönnemann C., Kunkel L., Bhattacharya S. K., Lotz B.P., Waclawik A.J.
Extract | Full Text  
N Engl J Med 1996; 334:1610-1611, Jun 13, 1996. Correspondence

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