Abnormalities of glucose, insulin, and lipoprotein metabolismare common in patients with hypertension. These changes canalso be discerned in normotensive first-degree relatives ofhypertensive patients. They are not present in patients withsecondary forms of hypertension, do not necessarily improvewhen blood pressure is lowered pharmacologically, and may evenbe made worse by some forms of antihypertensive treatment. Thesemetabolic abnormalities may play a part in both the pathogenesisand the complications of hypertension in many patients. We hypothesizethat the metabolic abnormalities are linked to the hypertensionby a pathophysiologic process that involves the sympathoadrenalsystem and exerts . . . [Full Text of this Article]
Glucose, Insulin, and Lipoproteins in Patients with Hypertension
Hypertension and Metabolic Disorders
Metabolic Abnormalities and the Clinical Course of Patients with Hypertension
Dyslipidemia and Coronary Heart Disease
Insulin Resistance, Sympathoadrenal Activity, and Hypertension
Diet and Sympathetic Nervous System Activity
Role of Insulin
Dietary Thermogenesis
Obesity-Related Hypertension
Insulin and Sympathetic Activity in Hypertension
Insulin Resistance in Nonobese Patients with Hypertension
Vasodilator Actions of Insulin
Dyslipidemia
Effects of Antihypertensive Drugs on the Sympathetic Nervous System
-Adrenergic Antagonists
1-Adrenergic Antagonists
Blood Flow
Other Antihypertensive Drugs
Effects of Antihypertensive Drugs on Lipoprotein Metabolism
-Adrenergic Antagonists
1-Adrenergic Antagonists
Conclusions
Source Information
From Stanford University, Palo Alto, Calif. (G.M.R.); Uppsala University, Uppsala, Sweden (H.L.); and Northwestern University, Chicago (L.L.).
Address reprint requests to Dr. Landsberg at the Department of Medicine, Northwestern University Medical School and Northwestern Memorial Hospital, Wesley Pavilion 296, 250 E. Superior St., Chicago, IL 60611.
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-Adrenergic Antagonists
1-Adrenergic Antagonists
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