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Correspondence
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Volume 334:402-404 February 8, 1996 Number 6
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Vaccination against Influenza in Healthy Adults

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by Patriarca, P. A.
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by Nichol, K. L.
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To the Editor: Nichol et al. (Oct. 5 issue)1 report that during one influenza season, immunization against influenza significantly reduced the frequency of respiratory illness in healthy, working adults. About three quarters of the subjects had not previously been immunized. Our concern is whether subsequent influenza shots given annually would be as effective as they are the first time they are administered. Hoskins et al.2 studied the effectiveness of annual vaccinations against influenza at a boys' boarding school and found that over a four-year period, the cumulative attack rate for three successive outbreaks (approximately 40 to 50 percent) was the . . . [Full Text of this Article]

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