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Previous Volume 334:404-406 February 8, 1996 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Hummel et al. (Oct. 5 issue)¹ report the polyclonality of Reed–Sternberg cells in 6 of 12 cases of Hodgkin's disease. In three other cases, there were mixed polyclonal and monoclonal populations of Reed–Sternberg cells, and in three cases the cells were monoclonal. We are concerned about the reported results of this study.

In an analysis of single Reed–Sternberg cells micromanipulated from frozen tissue sections for heavy-chain (VH) and kappa light-chain (V) gene rearrangements, we detected clonal V gene rearrangements in 11 of 12 cases investigated, 3 which have already been reported.² No rearrangements . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Tzankov, A., Krugmann, J., Fend, F., Fischhofer, M., Greil, R., Dirnhofer, S. (2003). Prognostic Significance of CD20 Expression in Classical Hodgkin Lymphoma: A Clinicopathological Study of 119 Cases. Clin. Cancer Res. 9: 1381-1386 [Abstract] [Full Text]  
• Hasse, U., Tinguely, M., Leibundgut, E. O., Cajot, J.-F., Garvin, A. M., Tobler, A., Borisch, B., Fey, M. F. (1999). Clonal Loss of Heterozygosity in Microdissected Hodgkin and Reed-Sternberg Cells. JNCI J Natl Cancer Inst 91: 1581-1583 [Full Text]