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Previous Volume 334:461-463 February 15, 1996 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The association of anemia with renal failure was noted by Richard Bright 160 years ago.¹ Anemia develops early in the course of renal failure, becomes prominent as the disease progresses, and contributes substantially to disability. Patients with renal failure have lower plasma levels of erythropoietin and less erythropoiesis than other patients with similar degrees of anemia, implicating inadequate production of erythropoietin by the diseased kidney as the primary mechanism of the anemia of renal failure. Other factors may also contribute, including "uremic toxins" that inhibit erythropoiesis, occult blood loss, hemolysis, and deficiencies in folate, iron, or both.

Recombinant human erythropoietin . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Kalantar-Zadeh, K., Aronoff, G. R. (2009). Hemoglobin Variability in Anemia of Chronic Kidney Disease. J. Am. Soc. Nephrol. 20: 479-487 [Abstract] [Full Text]  
• Urena, P., Petrover, M., Levin, N. W., Gotch, F., Malhotra, D., Tzamaloukas, A. H., Ballinger, A. B., Fairclough, P. D., Clark, M. L., Farthing, M. J.G., Kotanko, P., Ifudu, O., Feldman, J., Friedman, E. A. (1996). Intensity of Hemodialysis and Response to Erythropoietin. NEJM 334: 1669-1671 [Full Text]