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Previous Volume 334:463-466 February 15, 1996 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Postnatal growth and, to a much lesser degree, intrauterine growth are critically dependent on the expression of the pituitary growth hormone GH-1 gene and the consequent generation of insulin-like growth factor I (IGF-I) in the liver and other tissues. The secretion of growth hormone is determined by an interplay between growth hormone–releasing hormone and an inhibitory hormone, somatostatin.

Growth hormone–releasing hormone, which is secreted by the arcuate nucleus and premamillary area of the hypothalamus, increases the synthesis as well as the secretion of growth hormone. Somatostatin is also secreted by the arcuate nucleus of the hypothalamus. Pituitary tissue contains a . . . [Full Text of this Article]

References

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• Garcia-Fernandez, M., Delgado, G., Puche, J. E., Gonzalez-Baron, S., Castilla Cortazar, I. (2008). Low Doses of Insulin-Like Growth Factor I Improve Insulin Resistance, Lipid Metabolism, and Oxidative Damage in Aging Rats. Endocrinology 149: 2433-2442 [Abstract] [Full Text]  
• Puche, J. E., Garcia-Fernandez, M., Muntane, J., Rioja, J., Gonzalez-Baron, S., Castilla Cortazar, I. (2008). Low Doses of Insulin-Like Growth Factor-I Induce Mitochondrial Protection in Aging Rats. Endocrinology 149: 2620-2627 [Abstract] [Full Text]