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Previous Volume 334:469-472 February 15, 1996 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Goldstein, A. M. PubMed Citation

To the Editor: The studies by Goldstein and Whelan and their colleagues (Oct. 12 issue)^1,2 indicate that p16 mutations are required for the development of pancreatic cancer in 10 melanoma-prone kindreds in the United States, Australia, and the Netherlands, which were previously characterized with respect to chromosome 9p21 by linkage analysis. We have found evidence relating the risk of pancreatic adenocarcinoma to a p16 mutation in bloodline members of melanoma-prone Italian families.

So far, within a small geographic area of Italy (possibly because of a founder effect), we have detected the same Gly93Trp mutation in seven apparently unrelated families and . . . [Full Text of this Article]

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