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Correspondence
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Volume 334:473-474 February 15, 1996 Number 7
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Association of Interleukin-6 and Hypoaldosteronism in Patients with Cancer

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To the Editor: Patients with cancer may have a variety of metabolic and immunologic abnormalities that are thought to be caused by different humoral factors secreted by the tumors and are called paraneoplastic syndromes.1 We have seen several patients with cancer with unexplained hyperkalemia that we attributed to a paraneoplastic process.

Among 82 patients with cancer who were admitted to our hospital in 1993, 3 were identified with persistent hyperkalemia that could not be attributed to renal failure, pseudohyperkalemia, or drugs.2,3 These three patients underwent detailed studies of renal function, electrolyte metabolism, and the renin–angiotensin–aldosterone system and had measurements of . . . [Full Text of this Article]

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