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Previous Volume 334:580-585 February 29, 1996 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The endogenous catecholamines — norepinephrine and epinephrine — are involved in the regulation of virtually every organ system. Norepinephrine acts as a neurotransmitter at certain sites in the central nervous system and in the sympathetic nervous system at postganglionic neuroeffector junctions. Epinephrine is primarily a circulating hormone produced by the adrenal medulla and other chromaffin tissue. Because norepinephrine comes from chromaffin tissue and overflows from sympathetic-nerve synapses, plasma concentrations of norepinephrine exceed those of epinephrine. Hence, norepinephrine can also act as a circulating hormone.

Norepinephrine and epinephrine act through adrenergic receptors (also termed adrenoceptors). In this review, I will summarize . . . [Full Text of this Article]

Types and Subtypes of Adrenergic Receptors

Adrenergic Receptors and Regulation of Target-Cell Function

Target-Cell Regulation of Adrenergic Receptors

Clinical Settings in Which Alterations in Adrenergic Receptors Contribute to Pathophysiology

Conclusions

Discussion

Source Information

From the Departments of Pharmacology and Medicine, University of California, San Diego.

Address reprint requests to Dr. Insel at the Department of Pharmacology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093.

References

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