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Previous Volume 334:599-600 February 29, 1996 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Polvikoski, T. PubMed Citation

To the Editor: Polvikoski et al. (Nov. 9 issue)¹ have convincingly demonstrated that there is a greater accumulation of -amyloid protein in the brain and more neurofibrillary tangles in elderly Finnish subjects with the 4 allele of apolipoprotein E than in those without it.

We recently investigated the relation between the apolipoprotein E genotype and the density of senile plaques and number of neurofibrillary tangles in 69 elderly Japanese patients. Among these subjects, 49 did not have dementia (age at death, 86.2±7.8 years) and 20 had Alzheimer's disease (age at death, 83.8±8.3 years). Two subjects had the 2/3 genotype, . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Sodeyama, N, Itoh, Y, Suematsu, N, Matsushita, M, Otomo, E, Mizusawa, H, Yamada, M (1998). Presenilin 1 intronic polymorphism is not associated with Alzheimer type neuropathological changes or sporadic Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 64: 548-551 [Abstract] [Full Text]