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Previous Volume 335:54-55 July 4, 1996 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Many medical treatments are based on sheer empiricism. In 1975 I noted that trimethoprim–sulfamethoxazole had a salutary effect in a woman with Wegener's granulomatosis involving all major sites, including the upper respiratory tract, lungs, and kidneys. I had given her the drugs to treat a urinary tract infection, reasoning that standard immunosuppressant therapy with a glucocorticoid and cyclophosphamide would cause a disseminated infection. Since the disease had a somewhat indolent course, I elected first to treat the urinary tract infection, which was due to Escherichia coli sensitive to trimethoprim–sulfamethoxazole. Curiously, the disease came under control at all sites. During the . . . [Full Text of this Article]

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